Stay Cool with Divigel® The #1 prescribed transdermal estrogen gel.1

Divigel® is FDA-approved to treat moderate to severe vasomotor symptoms (hot flashes and night sweats) due to menopause.

Divigel® comes in 0.25 mg, 0.5 mg, 0.75 mg, and 1 mg.

Proven Relief From Hot Flashes and Night Sweats

  • Eliminated nearly 90% of hot flashes in 12 weeks at the highest dose strength (1 mg/day).2
  • Reduced hot flashes by nearly HALF in as little as 2 weeks (1 mg/day).2
  • Comes in four dose strengths, including the lowest FDA approved dose.3
  • At the lowest dose (0.25 mg/day) Divigel® eliminated about 70% of hot flashes in 12 weeks.2

The FDA recommends the lowest effective dose with any estrogen therapy.3,4 Only Divigel® offers the lowest dose of topical estrogen gel or spray available for hot flashes (0.25 mg/day estradiol)3

Gel droplet.

Cool, Discreet Gel

  • Divigel® is a gel that leaves no sticky residue.
  • It’s invisible and odorless when dry. Nobody knows you’re wearing it.
  • It’s a concentrated estradiol gel, so only a small amount is needed for big relief.

Hand holding a Divigel® (estradiol gel) discreet packet.

Easy to Use and Convenient

  • A small amount of Divigel® is applied once daily to the upper thigh.
  • The gel comes in small, discreet, portable packets that are easy to use at home and great for travel.
  • Premeasured, daily packets ensure precise, accurate dosing.
  • Divigel® becomes part of your daily personal care routine.


Although the clinical significance has not been determined, estradiol from Divigel® does not undergo first pass metabolism.


Easy to Apply Once Daily Cool Relief


Woman consulting her doctor.
Icon illustrating that Divigel's transdermal estrogen gel formula can  be applied directly to the upper thigh.


Ask your doctor for a free sample of Divigel® to help you get started. Each sample comes with 7 days of therapy and a travel case. Your doctor can order samples here.


We offer a copay savings program. Divigel® is covered by most commercial insurance companies. Bring your prescription to the pharmacy along with your coupon.

Icon illustrating that Divigel's transdermal estrogen gel formula can  be applied directly to the upper thigh.


Learn how to apply Divigel®, what to know before you start and find answers to common questions.

1. This information is an estimate derived from the use of information under license from the following IQVIA information service: NPA™, for the period 2018. IQVIA expressly reserves all rights, including rights of copying, distribution and republication.
2. Hedrick RE, Ackerman RT, Koltun WD, Halvorsen MB, Lambrecht LJ. Transdermal estradiol gel 0.1% for the treatment of vasomotor symptoms in postmenopausal women. Menopause. 2009;16(1):132-140.
3. accessed April 27, 2018.
4. US Food and Drug Administration. Menopause and hormones. Updated June 14, 2017. Accessed July 18, 2017.
5. Goodman NF, Cobin RH, Ginzburg SB, Katz IA, Woode DE; American Association of Clinical Endocrinologists. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of menopause. Endocr Pract. 2011;17(suppl 6):1-25.
6. Samsioe G. Transdermal hormone therapy: gels and patches. Climacteric. 2004;7(4):347-356.

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