Stay Cool with Divigel®

Divigel® is FDA-approved to treat moderate to severe vasomotor symptoms (hot flashes and night sweats) due to menopause.

Divigel® comes in 0.25 mg, 0.5 mg, 0.75 mg, 1 mg and 1.25 mg.

Proven Relief From Hot Flashes and Night Sweats

  • Eliminated nearly 90% of hot flashes by 12 weeks with 1 mg/day.1
  • Reduced hot flashes by nearly HALF in as little as 2 weeks (1 mg/day).1
  • Comes in five dose strengths, including the lowest FDA approved dose.2
  • At the lowest dose (0.25 mg/day) Divigel® eliminated about 70% of hot flashes in 12 weeks.1

The FDA recommends the lowest effective dose with any estrogen therapy.2,3 Only Divigel® offers the lowest dose of topical estrogen gel or spray available for hot flashes (0.25 mg/day estradiol)2

Use estrogen-alone, or in combination with progestin, at the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman.

Gel droplet.

Cool, Discreet Gel

  • Divigel® is a gel that leaves no sticky residue.
  • It’s invisible and odorless when dry. Nobody knows you’re wearing it.
  • It’s a concentrated estradiol gel, so only a small amount is needed for big relief.

Hand holding a Divigel® (estradiol gel) discreet packet.

Easy to Use and Convenient

  • A small amount of Divigel® is applied once daily to the upper thigh.
  • The gel comes in small, discreet, portable packets that are easy to use at home and great for travel.
  • Premeasured, daily packets ensure precise, accurate dosing.
  • Divigel® becomes part of your daily personal care routine.


Although the clinical significance has not been determined, estradiol from Divigel® does not undergo first pass metabolism.


Easy to Apply Once Daily


Woman consulting her doctor.
Icon illustrating that Divigel's transdermal estrogen gel formula can  be applied directly to the upper thigh.


Ask your doctor for a free sample of Divigel® to help you get started. Each sample comes with 7 days of therapy and a travel case. Your doctor can order samples here.

Icon illustrating that Divigel's transdermal estrogen gel formula can  be applied directly to the upper thigh.


Learn how to apply Divigel®, what to know before you start and find answers to common questions.

1. Hedrick RE, Ackerman RT, Koltun WD, Halvorsen MB, Lambrecht LJ. Transdermal estradiol gel 0.1% for the treatment of vasomotor symptoms in postmenopausal women. Menopause. 2009;16(1):132-140.
2. Orange Book: Approved Drug Products with Therapeutic equivalence Evaluations. U.S. Food & Drug Administration. Accessed February 13, 2020.
3. US Food and Drug Administration. Menopause. Updated August 22, 2019. Accessed February 13, 2020.

Alpharetta, GA 30005